Halin: Immunodeficiency
Definition
What are primary immunodeficiencies? What are secondary immunodeficiencies?
How does chemotherapy lead to secondary immunodeficiency?
Give example of severe primary immunodeficiency? I said X-linked aggammaglobulinemia --> not correct, can be treated relatively easily,
then I said X-linked severe combined immunodeficiency
What is mechanism of X-SCID?
What kind of infections will someone have with X-linked agammaglobulinemia?
Neri: Insulin
Tell me about Insulin.
When was the first recombinant insulin available? Which company?
What types of Insulin are available?
How is it produced? e.coli
What is the structrue of insulin? -> disulphide bonds can not be produced directly in e.coli
What are strategies for prolonging half-life?