Halin: Morbus Crohn
- could tell everything I knew about the disease
- about NOD2 / pattern recognition receptors in general: what do they recognize?
- what happens if a bacterium reaches the submucosa?
- why are TH1 / TH17 responses mounted? what cytokines are released? what are the effects?
- do you know a disease where IL-17 plays a role in the disease pathology?
- what happens in the presence of non- invasive bacteria?
Neri: Clearance of therapeutic proteins
- how are small molecules / big molecules excreted? (small: kidney, big: liver)
- why do antibodies have a long half-life?
- explanation of FcRn recycling
- do you know of any therapeutic proteins that have a short half-life?
- Abciximab: Fab-fragment hat binds GPIIb/IIIa repector on platelets and inhibits platelet aggregation
- why does plattelet aggregation returns to normal only after 4-5d? (due to its high affinity)