Halin: Transplant rejection
- What do you know about transplant rejection? -> explained blood group etc.
- What does IgM do? (in the context of blood group) -> complement activation
- End-point effect of complement activation? (in the context of blood group) -> opsonisation of erythrocytes by macrophages, pore formation of erythrocytes
- What about MHC? -> polygenic, polymorph, direct & indirect rejection of graft
- From which family members would you like to receive an organ transplant from? -> from siblings, 25% chance of having same haplotypes
- If the MHC and blood group match, is it possible that the transplant will no longer be rejected? -> no, minor histocompatibility antigens different (due to SNPs)

Neri: Blood-derived therapeutic proteins
- Name one conventional therapeutic protein that is still used (e.g. derived from blood serum) -> antibody
- Why/For which patients? -> people with immunodeficiencies (e.g. XLA)
- Name one blood coagulation drug -> Hemlibra, explained function etc.
- Why not just inject recombinant factor VIII? -> immunogenicity
- In the lecture: saw a video about Hemlibra in clinical trial. What was measured/How was the efficacy of Hemlibra determined? -> measured bleeding of patients
- What is Reopro? -> fab fragment, block GPIIb/GPIIIa receptor on platelets
- Half-life of fab fragment? -> I guessed 1h
- How is fab cleared? -> through kidney
- Why use fab instead of antibody? -> don't want aggregation of platelets for a long time
- Name 3 events that may lead to blood coagulation (Virchow's triad) -> stasis of blood flow, endothelial injury, hypercoagulability